LONGITUDINAL TCR SEQUENCING REVEALS DONOR-DEPENDENT IMMUNE RECONSTITUTION PATTERNS AFTER PEDIATRIC ALLOGENEIC HSCT FOR PRIMARY IMMUNODEFICIENCIES (EHA 2026) - May 12, 2026 - Abstract #EHA-5090; PF1141; Pres time: Jun 12, 2026; 06:45 PM - 07:45 PM; Location: Hall A; "In contrast, letermovir administration did not significantly affect global TCR diversity at any time point...Newly generated donor-derived clones dominate long-term recovery, while virus-associated expansions reflect adaptive immune remodeling. TCR sequencing may support immune monitoring after pediatric transplantation."
Clinical • Acute Graft versus Host Disease • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Genetic Disorders • Graft versus Host Disease • Immunology • Pediatrics • Primary Immunodeficiency
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Guanghua Zhu 1; Wei Yang 1; Jie Zheng 1; Bin Wang 1; Yanhui Luo 1; Jun Yang 1; Chenguang Jia 1; Yuanfang Jing 1; Wei Chen 1; Shunjin Zhang 2; Xiaoxia Wang 2; Jinghua Wu 2; Xiao Liu 3; Maoquan Qin1
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