LETERMOVIR USE IN PEDIATRIC HSCT PATIENTS UNDER 12 YEARS OLD: UPDATED DATA FROM A RETROSPECTIVE MULTICENTER STUDY OF THE PDWP AND IEWP OF THE EBMT (EBMT 2026) - Feb 7, 2026 - Abstract #OS09-05; Pres time: Mar 24, 2026; 09:36 AM - 09:45 AM; Location: N104; "Conditioning regimens included treosulfan-based (44.5%), TBI-based (32.2%), busulfan-based (15.1%), and other (8.2%). In-vivo T-cell depletion (TCD) was used in 34.2% of patients (ATG 27.4%, Campath 6.8%), and ex-vivo TCD in 11.6%.Table 1: Patient and transplant characteristics With a median follow-up of 1 year (95% CI: 0.9–1.1), the 1-year cumulative incidence of CMV reactivation was 23.8% (95% CI: 16–30) overall, 21.4% (95% CI: 13.6–29.2) during primary prophylaxis, and 32.6% (95% CI: 13.1–45) during secondary prophylaxis (Figure 1)...Among patients with CMV reactivation, one death was attributed to relapsed disease.Letermovir was well tolerated with only two patients experiencing mild gastrointestinal toxicity, and no additional significant adverse events reported.CMV reactivations were managed using standard antiviral strategies, including valganciclovir (n=10), ganciclovir (n=8), foscarnet (n=7), and cidofovir (n=1) or continued letermovir alone (n=8)... In..."
Retrospective data • Bone Marrow Transplantation • Cytomegalovirus Infection • Graft versus Host Disease • Hepatology • Immunology • Infectious Disease • Pediatrics
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Claire Horgan1; Katharina Kleinschmidt2; Giovanna Lucchini3; Mouad Abouqateb4; Jacques-Emmanuel Galimard4; Adriana Balduzzi3; Nathanael Lucas5; Krzysztof Czyzewski6; Peter Svec7; Gergely Krivan8; Jan Styczynski8; Joern Sven9; Kanchan Rao10; Marta Gonzalez Vicent11; Robert Wynn1; Francesco Paulo Tamboro12; Wing Roberts13; Alessandra Biffi14; Ivan Lopez Torija15; Renata Formankova16; Wolfgang Holter17; Christina Peters17; Tamara Diesch-Furlanetto18; Andrea Urtasun19; Mathias Wölfl20; Jowita Frączkiewicz21; Maria Ester Bernado22; Michael H. Albert23; Agnieszka Sobkowiak-Sobierajska2524; Elif Ince25; Roland Meisel26; Arnaud Dalissier4; Selim Corbacioglu2; Bénédicte Neven27; Krzysztof Kalwak21
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