Acyclovir-Resistant Herpes Simplex Virus in Pediatric Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant: A Case Series. (PubMed, Transpl Infect Dis) - Jan 14, 2026 - "Acyclovir-resistant HSV infection in pediatric HSCT recipients is associated with high morbidity and mortality, limited therapeutic options, and significant treatment-related nephrotoxicity. Early recognition, early resistance testing, prompt initiation of second-line therapy, and weaning of immunosuppression are critical. Emerging therapies, such as helicase-primase inhibitors and adoptive T-cell therapy, hold promise but remain limited by access and pediatric data."
Journal • Bone Marrow Transplantation • Gastrointestinal Disorder • Genetic Disorders • Graft versus Host Disease • Hematological Disorders • Hematological Malignancies • Herpes Simplex • Immunology • Infectious Disease • Keratitis • Leukemia • Myelodysplastic Syndrome • Ocular Inflammation • Oncology • Ophthalmology • Pediatrics • Pneumonia • Primary Immunodeficiency • Respiratory Diseases • Sickle Cell Disease • Transplantation
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Ahmed Ahmed; Claire Horgan; Denise Bonney; Jenna Nunn; Malcolm Guiver; Oana Mirci-Danicar; Omima Mustafa; Ramya Nataraj; Robert Wynn; Srividhya Senthil
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