Cytomegalovirus IL-10 in Plasma as a Marker of Active Infection in Allogeneic Hematopoietic Transplant Recipients: An Exploratory Study. (PubMed, J Med Virol) - Jan 13, 2026 - "We investigated whether plasma cytomegalovirus (CMV) IL-10 (cmvIL-10) levels could serve as a biomarker of active CMV replication in allogeneic hematopoietic transplant recipients (allo-HCT) in the presence or absence of letermovir (LMV) prophylaxis...An AUC₁₄₋₂₃ cutoff value of log10 3.06 discriminated anticipately between CsCMVi and non-CsCMVi with a sensitivity and specificity of 100%. Plasma cmvIL-10 levels may reflect true CMV replication and thus provide a unique perspective on viral dynamics, serving as an ancillary marker to CMV DNA monitoring."
Biomarker • Journal • Bone Marrow Transplantation • Cytomegalovirus Infection • Infectious Disease • Transplantation • IL10
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Ángela Sánchez-Simarro; Ariadna Pérez; Carlos Solano; David Navarro; Eliseo Albert; Estela Gimenez; Ester Colomer; Jose Luis Piñana
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