Cytomegalovirus and Crohn's disease as competing causes of small bowel inflammation after double-lung transplantation. (PubMed, Eur Clin Respir J) - Dec 3, 2025 - "CMV infection was identified in intestinal biopsies and initially managed with two courses of valganciclovir. Due to persistent symptoms, genotypic analysis was performed, revealing UL97 mutations conferring ganciclovir resistance. Sequential therapy with foscarnet, maribavir, and letermovir achieved virological clearance, but diarrhea persisted...The patient was commenced on standard biological therapy for Crohn's disease, resulting in marked clinical improvement and recovery. This case illustrates the diagnostic challenge of distinguishing CMV enteritis from de novo Crohn's disease and determining the primary driver of the clinical presentation."
Journal • Crohn's disease • Cytomegalovirus Infection • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Mucositis • Respiratory Diseases • Solid Organ Transplantation • Transplantation
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Christian Lodberg Hvas; Elisabeth Bendstrup; Julie Hansen Niklassen; Kasper Sommerlund Moestrup; Kristian Schønning; Marie Helleberg; Michael Perch
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