New Insights Into Factors Shaping CMV-Specific T-Cell Polyfunctionality After Hematopoietic Cell Transplantation. (PubMed, Am J Hematol) - Dec 1, 2025 - "We conducted a comparative analysis of how timing and dosing of immunosuppressive agents, including post-transplant cyclophosphamide (PT-Cy), corticosteroids, mycophenolate mofetil (MMF), and calcineurin inhibitors (CNIs), shape CMV-specific T-cell polyfunctionality. CD4+ and CD8+ T-cell responses (IFN-γ plus ≥ 1 functional marker) were assessed following pp65 stimulation within 100 days post-HCT in the pre- and post-letermovir era...Cyclosporine was associated with higher frequencies of polyfunctional T cells compared to tacrolimus, even at concentrations above the therapeutic range...These findings provide novel insights into the importance of timing and dosing of the immunosuppressive effects of PT-Cy, corticosteroids, MMF and CNIs on CMV-specific immunity. Adjusting immunosuppression in specific time windows may improve the management of refractory CMV infections and optimize VST in HCT recipients."
Journal • Cytomegalovirus Infection • Infectious Disease • Transplantation • CD4 • CD8 • IFNG
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Alicja Sadowska-Klasa; Bradley C Edmison; Danniel Zamora; Fang Yun Lim; Hu Xie; Marco Mielcarek; Michael Boeckh; Stephen C De Rosa; Terry Stevens-Ayers; Wendy M Leisenring
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