Mini-ATG/TBI conditioning regimen facilitates cure of acquired aplastic anemia in children via unrelated umbilical cord blood transplantation (ASH 2025) - Nov 4, 2025 - Abstract #abs25-9329; 2420; Pres time: Dec 6, 2025; 05:30 PM - 07:30 PM; Location: OCCC - West Halls B3-B4; P4 | "The mini-ATG/TBI regimen comprised: rabbit ATG (rATG, 2.5 mg/kg)on day -7, total body irradiation (TBI, 3 Gy) on day -7, fludarabine (FLU, 40 mg/m²) on days -6 to -2, andcyclophosphamide (CTX, 40 mg/m²) on days -4 and -2...In the mini-ATG/TBI group,odd-numbered patients received avatrombopag starting on day +7 to promote platelet engraftment,while even-numbered patients received thrombopoietin (TPO)... These data support the mini-ATG/TBI regimen as an effective conditioning approach forUCBT in acquired aplastic anemia, demonstrating particular utility in pediatric patients or low bodyweight adults.Key words: Aplastic Anemia; Unrelated Umbilical Cord Blood Transplantation; mini ATG"
Clinical • Acute Graft versus Host Disease • Anemia • Aplastic Anemia • Epstein-Barr Virus Infections • Graft versus Host Disease • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Immunology • Infectious Disease • Septic Shock • Transplantation
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Xia Chen1; yuanyuan ren1; Ye Guo1; yang wan1; Lipeng Liu1; xiaoyan zhang1; Xiaolan Li1; Xiaofan Zhu1; Wenyu Yang1; Fang Liu1
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