The Parkinson's Disease Drug Tolcapone and Analogues are Potent Glycomimetic Lectin Inhibitors of Pseudomonas aeruginosa LecA. (PubMed, Angew Chem Int Ed Engl) - Nov 3, 2025 - "Motivated by the pressing need for new anti-infective therapies caused by antimicrobial resistance, inhibitors of LecA are under investigation. This work paves the way for a new avenue of research towards innovative anti-infective drugs. In a more general perspective, such small molecules also hold potential to challenge the hegemony of antibodies for lectin inhibition in clinical use."
Journal • CNS Disorders • Movement Disorders • Parkinson's Disease
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Alexander Titz; Annabelle Varrot; Anne Imberty; Bernd Kuhn; Christian Lerner; Eike Siebs; Sakonwan Kuhaudomlarp; Steffen Leusmann; Uwe Grether
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