Discovery of a Baloxavir-Inspired Endonuclease Inhibitor That Prevents Herpes Simplex Virus 1 Replication in Cell Culture and In Vivo. (PubMed, Adv Sci (Weinh)) - Sep 16, 2025 - "Acyclovir and other viral DNA polymerase inhibitors are effective antiviral agents for treating HSV infections. However, despite the recent approval of pritelivir and amenamevir (helicase-primase complex inhibitors), drug resistance is still a major threat to therapeutic success...LN-7 demonstrates antiviral efficacy in infected mice, while exhibiting fewer clinical signs compared to controls. Overall, LN-7 emerges as a promising lead for treating herpesvirus infections and is therefore a first-in-class drug candidate targeting HSV genome packaging."
Journal • Preclinical • Herpes Simplex • Infectious Disease
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Daniel Galdo-Torres; Federico Gago; Gabriel Pino-Peco; Jiahui Zhou; José Antonio López-Guerrero; Kai Tang; Lina Zhang; Luis Menéndez-Arias; Nerea Lopez-Carrobles; Peng Zhan; Raquel Bello-Morales; Sabina Andreu; Xinyong Liu
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