Time shift in ciclosporin metabolism downregulation by inflammation in allogeneic hematopoietic cell transplantation: A time-dependent transduction modelling PK-PD approach. (PubMed, Eur J Pharm Sci) - Sep 14, 2025 - "1994 and 2 patients with potential drug-drug interactions (pDDI) involving letermovir from our cohort. Our results provide the first quantitative evidence of time-dependent inhibition due to inflammation of ciclosporin metabolism. This quantitative modeling framework may inform dose adjustment and DDI risk evaluation in inflammatory conditions, particularly in allogeneic HSCT patients."
Journal • PK/PD data • Bone Marrow Transplantation • Inflammation • Transplantation • CRP • CYP3A4
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David Malnoë; Pascal Le Corre; Tony Marchand
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