A New Next-Generation Sequencing Approach in Human Cytomegalovirus for the Identification of Antiviral Resistance Mutations and Genotypic Classification. (PubMed, J Med Virol) - Jul 30, 2025 - "It expands the classical investigation of mutations in UL54 and UL97 genes, associated with resistance to (val)ganciclovir, foscarnet and cidofovir, to include UL27, UL56 and UL89 genes, which target newer antivirals like maribavir and letermovir. Finally, this approach enabled the identification of HCMV genotypes. This approach improves the monitoring of antiviral resistance and viral diversity, enhancing early clinical decision-making in immunocompromised patients."
Biomarker • Journal • Next-generation sequencing • Cytomegalovirus Infection • Infectious Disease
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Adaia Albasanz-Puig; Alejandra González-Sánchez; Andrés Antón; Ariadna Rando-Segura; Cristina Andrés; Ibai Los Arcos; Ignasi Prats-Méndez; Juliana Esperalba; Maria Arnedo-Muñoz; María Carmen Martín; María Piñana; Marta Bernat-Sole; Narcís Saubi; Natalia Mendoza-Palomar; Nieves Larrosa; Patricia Nadal-Baron; Susana Melendo-Pérez
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