PRE-TRANSPLANT MNGS-GUIDED LETERMOVIR PROPHYLAXIS REDUCES POST-HSCT CMV REACTIVATION: A PROSPECTIVE RISK STRATIFICATION STUDY (EHA 2025) - May 16, 2025 - Abstract #PF1067; Pres time: Jun 13, 2025; 06:30 PM - 07:30 PM; Location: Poster Hall; "Pre-transplant mNGS detection of CMV sequences identifies high-risk patients for breakthrough reactivation despite LET prophylaxis correlating with inferior survival. Risk stratification incorporating mNGS quantification conditioning intensity BMI and CMV history may optimize prophylactic strategies. These findings advocate for mNGS-based algorithms to guide precision CMV prevention in allo-HSCT."
Clinical • Pre-transplantation • Bone Marrow Transplantation • Cytomegalovirus Infection • Epstein-Barr Virus Infections • Hematological Malignancies • Infectious Disease • Oncology • Transplantation
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Mingqi Yang; Qingya cui; Zheng li; Mengyun Li; Yan Yu; Sifan Chen; Wei Cui; Xin Zhang; Juan Chen; Xuekai Li; Xiaoqian Chen; Yunju Ma; Sining Liu; Depei Wu; Xiaowen Tang
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