Surveillance of CMV Terminase Gene Mutations in Allogeneic Hematopoietic Stem Cell Transplant Recipients Receiving Letermovir Prophylaxis. (PubMed, J Med Virol) - Jul 11, 2026 - "Clinically significant CMV infections were successfully managed with preemptive therapies. This study confirms the efficacy of LMV prophylaxis and demonstrates that LMV exerts selective pressure on the terminase complex, increasing the risk of resistance when CMV DNA levels exceed 3 log IU/mL, underscoring the importance of timely consideration of alternative antiviral therapies when CMV replication persists."
Journal • Retrospective data • Bone Marrow Transplantation • Cytomegalovirus Infection • Infectious Disease • Transplantation
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Aliénor Xhaard; Amandine Caillault; David Michonneau; Eléonore Kaphan; Flore Sicre de Fontbrune; Florian Chevillon; Gérard Socié; Jérôme LeGoff; Julien Robert; Linda Feghoul; Marie Robin; Mathilde Ruggiu-Goiran; Matthieu Jestin; Maud Salmona; Nathalie Dhedin; Nathalie Schnepf; Pedro Henrique de Lima Prata; Régis Peffault de Latour; Séverine Mercier-Delarue
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