FEASIBILITY AND INTERIM SAFETY AND EFFICACY ANALYSIS OF A FAST AUTOMATED PRODUCTION OF PROPHYLACTIC CMV-SPECIFIC CTLs AFTER ALLOGENEIC HSCT. (PubMed, Transplant Cell Ther) - Jul 10, 2026 - "This interim analysis demonstrates the feasibility and acceptable safety profile of prophylactic infusion of donor-derived CMV-specific CTLs manufactured through a rapid automated process after allogeneic HSCT. Early results suggest a possible reduction in CMV reactivation without evidence of increased acute GVHD, although interpretation is limited by the small sample size. Ongoing recruitment and final study analysis will further define the clinical impact of this strategy."
Clinical • Journal • Acute Graft versus Host Disease • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Cytomegalovirus Infection • Developmental Disorders • Graft versus Host Disease • Immunology • Infectious Disease • Transplantation • IFNG
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Amaya LLorente-Mecieces; Andrés Insunza; Carlos Richard; Enrique M Ocio; Fermín Sánchez-Guijo; Gala A Méndez-Navarro; Íñigo Romón; José Luis Arroyo; Laura Álvarez-Montes; Lucía Lavín-Alconero; Ma Aránzazu Bermúdez; Marta Fernández-Martínez; Mercedes Colorado; Miriam Sánchez-Escamilla; Oscar M Pello; Patricia Maiso; Patricia Vega; Sara Fernández-Luis; Sara Vallejo-Diez
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