Altered Quinolinic Acid to Kynurenic Acid Ratios Are Associated with Indoleamine 2,3-Dioxygenase Pathway Activation in Neuropsychiatric Systemic Lupus Erythematosus (ACR Convergence 2026) - Sep 8, 2026 - Abstract #1979; Pres time: Nov 10, 2026; 10:30 AM - 12:30 PM; Location: WB1&2; In Person; "Mechanistic studies using healthy donor PBMCs cultured with SLE patient serum in the presence or absence of baricitinib evaluated by flow cytometric assessment of monocyte IDO expression... NPSLE is associated with enhanced IDO activity and downstream neuroactive metabolite imbalance, characterized by increased QA/KA ratios. The association of QA/KA ratios with serum-induced IDO expression and their sensitivity to JAK inhibition suggest that QA/KA may serve as a biomarker of IDO pathway activation and support therapeutic targeting of this pathway in NPSLE. Figure 1."
IO biomarker • Glomerulonephritis • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Psychiatry • Systemic Lupus Erythematosus • IDO1
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Yang Wu1; Ting Wang2; Alexandra Legge3; Christian Lood2
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