CAR-Tastrophe in the Gut: Two Cases of Immune Effector Cell-Associated Enterocolitis (ACG 2026) - Aug 29, 2026 - Abstract #P6608; Pres time: Oct 13, 2026; 10:30 AM - 04:00 PM; Location: Exhibit Halls A - D (Level 3); "Colonoscopy revealed edematous, erythematous, cobblestoned mucosa with loss of vascularity in the right colon involving the IC valve (Figure 1) and he was treated with vedolizumab in addition to IV steroids for concern of IEC-EC...CASE 2: A 74-year-old male with MM received CAR-T therapy (Carvykti)...Symptoms briefly improved with budesonide and cholestyramine, but later recurred...Ruxolitinib was associated with clinical improvement in both cases, suggesting it may be a promising treatment option. Figure: From Case 1: Mucosal edema, erythema, nodularity, cobblestoning, loss of vascularity, pale raised patches and ecchymosis seen in distal ascending colon and into cecum, involving the IC valve."
CAR T-Cell Therapy • Clinical • Febrile Neutropenia • Gastrointestinal Disorder • Hematological Malignancies • Multiple Myeloma
|
|
Lana Petrova MD 1; Timothy J. Lee MD 2; Philomena Burger BS 1; Brandon Sprung MD 2; Balaji Jagdish DO 1; Danielle Marino MD 3; Patrick Twohig MD MPH 1
|