RUNX3 drives HTR-8/SVneo cell ferroptosis and spontaneous abortion: involvement of the suppression of GDF15 transcriptional activity. (PubMed, Mol Cell Endocrinol) - Jul 29, 2025 - "Our findings revealed that RUNX3 overexpression accelerated trophoblast cell ferroptosis, while RUNX3 knockdown alleviated erastin-induced ferroptosis...Taken together, this study established that RUNX3 advanced SA progression by enhancing trophoblast ferroptosis via transcriptionally repressing GDF15. These findings may provide novel therapeutic strategies for SA management."
Journal • GDF15 • RUNX3 • TCF3
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Jie Zhang; Lanlan Cheng; Li Tan; Yungai Xiang
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