CDC25A Alleviates Obstructive Sleep Apnea-Hypopnea Syndrome With Hypertension and Inhibits Ferroptosis. (PubMed, J Sleep Res) - Jul 23, 2025 - "CDC25A overexpression in HUVECs ameliorated hypoxia-induced endothelial dysfunction by inhibiting ferroptosis and apoptosis and promoting cell survival; however, these protective effects were significantly abrogated by co-treatment with erastin. CDC25A inhibits OSAHS-hypertension progression and modulates ferroptosis-related pathways. This study identifies ferroptosis as a potential therapeutic target in OSAHS-associated hypertension, with CDC25A acting as a key regulatory factor."
Journal • Cardiovascular • Hypertension • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder • CDC25A • FANCD2 • GNRP • GPX4 • PARP1 • RRM2 • SLC7A11
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Chunsheng Wang; Deng Ouyang; Haofeng Xu; Huiling Ye; Ping Yan; Xin Yang; Zhile Wu
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