(+)-JQ-1 alleviates cardiac injury in myocardial infarction by inhibiting ferroptosis through the NAMPT/SIRT1 pathway. (PubMed, Cell Death Dis) - Jul 23, 2025 - "The combination of proteolysis-targeting chimeras (PROTACs) with JQ-1 (JQ-1-PROTAC) promoted BRD4 protein degradation and rescued erastin-induced ferroptosis in H9C2 cardiomyocytes, and prevented erastin-induced ferroptosis in human cardiomyocytes. Thus, JQ-1 can protect cardiomyocytes from ferroptosis through the NAMPT-SIRT1 pathway, and JQ-1-based therapy may serve as a novel promising strategy to improve cardiac remodeling after MI."
Journal • Cardiovascular • Myocardial Infarction • Targeted Protein Degradation • BRD4 • NAMPT
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Chunyan Wu; Huabing Sun; Jiao Liu; Jingrong Shao; Mengxue Yang; Ming Ji; Rui Xiao; Rui Zhao; Shengkai Zuo; Ting Wang; Weiping Tian; Xinna Ran
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