Amygdalin and magnesium ions exert synergistic effects on cartilage regeneration by inhibiting chondrocyte ferroptosis via the IL-17/GPX4 axis. (PubMed, J Orthop Translat) - Jul 18, 2025 - "IL-17A activated lipid peroxidation, leading to chondrocyte ferroptosis, while AMD suppressed IL-17 signalling, thereby mitigating the decrease in glutathione peroxidase 4 (GPX4) expression induced by IL-17A or erastin...A conservative therapeutic strategy involving joint injections of AMD (a natural plant extract) and Mg2+ (a crucial endogenous factor that promotes chondrogenesis) facilitated effective cartilage repair and regeneration. This strategy represents a cost-effective approach with potential for clinical application."
Journal • Age-related Macular Degeneration • Fibrosis • Immunology • Musculoskeletal Diseases • Orthopedics • Osteoarthritis • Pain • Rheumatology • GPX4 • IL17A
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Hanting Xia; Hongting Jin; Houfu Ling; Huihui Xu; Jiangyuan Liu; Jinjin Ma; Peijian Tong; Shuyan Zhang; Taotao Xu; Tianyou Ma; Xing Zhou; Xuefei Zhao; Yichen Lu; Yiwen Yang; Zhefei Xie; Zhengsheng Bao
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