Exosomes from tumor-associated neutrophils suppress ferroptosis and confer chemoresistance in gastric cancer via miR-9-3p/ACSL4 axis. (PubMed, Free Radic Biol Med) - Jul 19, 2025 - "Exosomes from miR-9-3p depleted N2 TANs showed a decreased effect on suppressing erastin-induced ferroptosis...Additionally, we found that exosomes from N2 TANs protected gastric cancer cells from ferroptosis induced by oxaliplatin, a commonly used drug for gastric cancer therapy, which could be rescued by targeted inhibition of miR-9-3p both in vitro and in vivo...Moreover, we revealed that the expression level of miR-9-3p was higher in human gastric cancer tissues than normal tissues and was negativity associated with patient survival. Conclusively, we reported a previous unclarified role of N2 TANs in chemoresistance via miR-9-3p-enriched exosomes-mediated downregulation of ASCL4 and the consequent suppression of ferroptosis, which may provide a new biomarker and therapeutic target for gastric cancer."
Journal • Gastric Cancer • Oncology • Solid Tumor • ACSL4
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Baiyuan Fan; Jiahui Zhang; Jiajin Xu; Jiayuan Shi; Jing Wang; Min Fu; Runbi Ji; Xiaotong Dong; Xiaoxin Zhang; Xinjian Fang; Xu Zhang; Yanzhen Wang; Yu Qian
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