Gut microbiota derived butyrate enhances ferroptosis sensitivity in endometriosis through FFAR2/PPAR-γ/PINK1/Parkin mediated mitophagy. (PubMed, Free Radic Biol Med) - Jul 17, 2025 - "Mechanistically, butyrate was found to enhance the sensitivity of cells to erastin-induced ferroptosis...Butyrate appears to counteract this by enhancing ferroptosis in ESCs via the FFAR2-mediated impairment of mitophagy. Therefore, butyrate shows potential as a therapeutic agent for the treatment of endometriosis."
Journal • Endometriosis • Gynecology • Inflammation • Women's Health
|
|
Beidi Wang; Hongli Wang; Honglin Wang; Jin Ding; Jing Cui; Jinming Liu; Ruru Bai; Yanling Gou; Yingying Cao; Zongfeng Zhang
|