Dual Targeting of BRAF V600E and Ferroptosis Results in Synergistic Anticancer Activity via Iron Overload and Enhanced Oxidative Stress. (PubMed, bioRxiv) - Jul 17, 2025 - "Targeting key regulators of ferroptosis-GPX4, using RSL3 and ML162, and system X c - , using erastin-induced significant cell death in all ATC cell lines. Additionally, dabrafenib-resistant BRAF V600E -mutant ATC cells were more sensitive to ferroptosis induction than parental cells. Dual targeting of BRAF V600E and ferroptosis results in synergistic anticancer activity and overcomes resistance to BRAF inhibition."
Journal • Endocrine Cancer • Hematological Disorders • Oncology • Solid Tumor • Thyroid Gland Anaplastic Carcinoma • Thyroid Gland Carcinoma • BRAF • GPX4
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Chandrayee Ghosh; Eden D Alamaw; Electron Kebebew; Jiangnan Hu; Myriem Boufraqech; Scott J Dixon; Tejinder P Khaket; Yasmine Tabdili; Zhongyue Yang
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