Perilipin 5 alleviates ferroptosis of cardiomyocytes by targeting USP10-p53-TfR proteasome-dependent degradation. (PubMed, Front Med (Lausanne)) - Jul 17, 2025 - "H9c2 cells were treated with H2O2 and Erastin, while the rat model of MI was established by ligating the left anterior descending coronary artery...USP10 and MG-132 blocked the regulatory effect of PLIN5 on TfR expression...In vivo experiments showed that overexpression of PLIN5 significantly reduced ferroptosis in the infarcted myocardium. Perilipin 5 may exert cardioprotective effects by regulating the USP10 and p53-TfR axis."
Journal • Cardiovascular • Metabolic Disorders • Myocardial Infarction • Targeted Protein Degradation • PLIN2 • USP1
|
|
Chengyuan Liu; Jiacheng Shui; Jianping Shen; Jianqiao Zhao; Qiyao Xu; Xindong Wang; Yuehong Shen
|