Blockade of Interferon-Induced Protein 35 Alleviates Cisplatin-Induced Ferroptosis in Acute Kidney Injury Through Activation of the NRF2. (PubMed, J Biochem Mol Toxicol) - Jul 14, 2025 - "The potential molecular mechanisms were examined in cells by detecting ferroptosis-related indicators following the addition of ferroptosis inducer (Erastin) and the antioxidant transcription factor NRF2 pathway inhibitor (ML385), respectively. Mechanistically, IFI35 inhibition reduced peroxide production, reversed iron-dependent mitochondrial damage, and inhibited ferroptosis via upregulating NRF2 activity. Our study suggested that IFI35 inhibition inhibits ferroptosis in AKI by upregulating NRF2 expression, targeting IFI35 may offer a promising therapeutic option for AKI."
Journal • Acute Kidney Injury • Nephrology • Renal Disease • AIFM2 • GPX4 • IFI35 • NFE2L2
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Fang Sun; Juan Zhou; Ye Liu
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