Metabolomic Analysis Identifies Betaine as a Key Mediator of TAp73α-Induced Ferroptosis in Ovarian Granulosa Cells. (PubMed, Int J Mol Sci) - Jul 13, 2025 - "In this study, we demonstrate that TAp73α overexpression promotes ferroptosis in bovine GCs by downregulating SLC7A11, depleting intracellular glutathione (GSH), and enhancing lipid peroxidation, particularly under Erastin treatment...Moreover, betaine co-treatment effectively reversed lipid peroxide accumulation and mitigated TAp73α-induced ferroptosis. Collectively, our findings identify a novel mechanism by which TAp73α promotes ferroptosis in granulosa cells through the suppression of betaine and glutathione metabolism, highlighting betaine as a key metabolic modulator with promising protective potential."
Journal • SLC7A11
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Bingfei Zhang; Le Chen; Liping Mei; Wenqiang Sun; Xianbo Jia; Xiang Gan
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