Tanshinone I promotes angiogenesis and improves ventricular remodeling post-myocardial infarction via ALDH2 signaling-mediated ferroptosis inhibition. (PubMed, Front Pharmacol) - Jul 11, 2025 - "In vitro experiments: Ferroptotic human umbilical vein endothelial cells (HUVECs) induced by erastin were treated with Tan I to assess ferroptosis, cell proliferation, migration, and tubular network formation...Additionally, Tan I inhibited ferroptosis, promoted proliferation and migration, and enhanced tubular network formation in HUVECs in vitro by activating ALDH2 and promoting ALDH2 signaling-related protein levels. Tan I may improve ventricular remodeling by activating ALDH2 signaling, inhibiting EC ferroptosis, and promoting angiogenesis."
Journal • Cardiovascular • Myocardial Infarction • ALDH2 • CD31 • GPX4 • PECAM1
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Dong Wang; Feng Zhang; Jian Sun; Lei Li; Qian Liu; Rong-Qiang Song; Wen-Long Wang; Xin-Chen Ren; Yi-Yi Zhang; Yu-Ting Wu; Zhi-Xin Wang
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