Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition. (PubMed, Adv Sci (Weinh)) - Jul 10, 2025 - "Further studies show that cystine deprivation or erastin-mediated transport inhibition increased PD-L1 expression in macrophages both in vitro and in vivo...At the same time, lung cancer patients with better responses to immunotherapy are found to have lower serum GSH levels. These findings suggest that targeting cystine metabolism combined with PD-L1 inhibition is a promising therapeutic strategy."
Checkpoint inhibition • IO biomarker • Journal • Lung Cancer • Oncology • Solid Tumor • CXCL10 • CXCL9 • TNFA
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Chenyang Wang; Jiaji Wu; Jianghao Yu; Jiangnan Zhao; Jin Cheng; Junhui Sun; Kai Wang; Lundqvist Andreas; Mengshu Li; Mo Shen; Nana Liu; Peng Xiao; Peng Yi; Pingli Wang; Shumin Li; Shumin Xu; Ying Yang; Yueli Shi; Yun Xu; Yunke Yang; Zhiyong Xu
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