CircASH1L inhibits ferroptosis and enhances cisplatin resistance by sponging miR-515-5p to regulate cell cycle-related CDCA7/RRM2 in ovarian cancer cells. (PubMed, Front Pharmacol) - Jul 9, 2025 - "circASH1L expression was downregulated upon erastin treatment and significantly upregulated in cisplatin-resistant A2780/DDP and SKOV3/DDP cells. The underlying mechanism involves the upregulation of miR-515-5p, which targets the CDCA7/RRM2 axis, leading to cell cycle modulation and the induction of ferroptosis. Targeting the circASH1L/miR-515-5p/CDCA7 pathway offers new insights into the relationship between ferroptosis and chemoresistance, presenting a promising strategy to overcome chemoresistance in ovarian cancer."
Journal • Oncology • Ovarian Cancer • Solid Tumor • RRM2
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Bin Su; Jiang Wang; Jun Li; Kang Liu; Longyu Tang; Lu Feng; Tianwen He; Xinru Zou; Yijun Yuan; Ying Tang
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