METTL3 increases ferroptosis resistance to facilitate the tumor-like features of rheumatoid arthritis synovial fibroblasts through enhancing SLC7A11 mRNA stability in an m6A-IGF2BP2-dependent manner. (PubMed, Int J Biol Macromol) - Jul 8, 2025 - "Furthermore, knockdown of METTL3 accelerated erastin-induced ferroptosis and further inhibited tumor-like characteristics in RASFs...Our findings indicate that the METTL3-mediated m6A modification plays a critical role in the pathogenesis of synovial hyperplasia and invasion in RA. Therapeutic interventions aimed at targeting METTL3 may offer a novel approach for the treatment of RA."
Journal • Immunology • Inflammatory Arthritis • Oncology • Rheumatoid Arthritis • Rheumatology • IGF2BP2 • METTL3 • SLC7A11
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Feihu Chen; Weirong Hu; Wenqiang Liu; Xiaoqing Peng; Xuewen Qian; Yayun Xu; Zhuoyan Zai
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