YLKTT, a potent biopeptide that ameliorates oxygen-glucose deprivation-induced neuronal cell ferroptosis by ACSL4/GPX4 and SLC7A11/GPX4 axis.

erastin - Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Columbia University, Prolexys

YLKTT, a potent biopeptide that ameliorates oxygen-glucose deprivation-induced neuronal cell ferroptosis by ACSL4/GPX4 and SLC7A11/GPX4 axis. (PubMed, J Pharm Pharmacol) - Jul 4, 2025 - "YLKTT can exert anti-ferroptosis effects through the ACSL4/GPX4 and SLC7A11/GPX4 pathways, thereby improving the treatment of cerebral ischemic injury."
Journal • Cardiovascular • Ischemic stroke • Reperfusion Injury • ACSL4 • GPX4 • SLC7A11

http://www.ncbi.nlm.nih.gov/pubmed/40613764

Guangjing Xu; Rui Li; Rui Liu; Saisai Song; Xiaoyu Wang; Xin Jin; Yansu Ji; Yuhan Wang; Yujie Wu; Zheng Li

Jul 4, 2025