Transcription factor TCF3 promotes bladder cancer development via TMBIM6-Ca2+-dependent ferroptosis. (PubMed, Cell Death Discov) - Jul 4, 2025 - "The bladder cells were overexpressed or silenced with TCF3/TMBIM6 with ferroptosis inducer (Erastin)/Ca2+ blocker (BAPTA-AM) to investigate the effects on Ca2+-dependent ferroptosis and other functions...Our findings demonstrate that TCF3 facilitates bladder cancer progression through the enhancement of TMBIM6-Ca2+-mediated ferroptosis resistance. Both TCF3 and TMBIM6 emerge as promising biomarkers and therapeutic targets for bladder cancer intervention."
Journal • Tumor mutational burden • Bladder Cancer • Genito-urinary Cancer • Oncology • Solid Tumor • BCL2L11 • GPX4 • SLC7A11 • TCF3 • TMBIM6
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Gang Fan; Jingfen Lu; Qing-Tian Luo; Wei-Feng Yang; Wei-Ming Guo; Yuan-Chun Ye; Zhou-Ke Tan
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