USP46 sensitizes BeWo trophoblasts to ferroptosis by stabilizing CIRBP. (PubMed, Integr Biol (Camb)) - Jul 3, 2025 - "Here we identified USP46 as a potent regulator of erastin-induced ferroptosis in BeWo trophoblasts, which serve as an in vitro model to study preeclampsia...USP46 interacts with CIRBP to reduce its ubiquitination and stabilize its expression, thereby promoting ferroptosis. This study reveals the key role of USP46 in regulating ferroptosis and provides a new target for etiological research and treatment of preeclampsia."
Journal • Cardiovascular • Gynecology • Hypertension • Renal Disease • Targeted Protein Degradation • USP46
|