Modified Qianghuo Shengshi Decoction Ameliorates Osteoarthritis via Inhibiting PI3K/Akt Pathway-Related Ferroptosis. (PubMed, J Cell Mol Med) - Jul 1, 2025 - "Network pharmacology was utilised to pinpoint disease targets, while various assays assessed ferroptosis-related chondrocyte phenotypes under Erastin or Ferrostatin-1 treatments...Molecular docking studies affirm the strong interaction between MQSD's key ingredients and the PI3K/Akt/GPX4 pathway components. Through modulation of ferroptosis via the PI3K/Akt pathway, MQSD retards OA progression."
Journal • Immunology • Osteoarthritis • Pain • Rheumatology • ANXA5 • GPX4 • IL1B
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Chen Zhuang; Chenxuan Hong; Enli Li; Lei Yang; Wen-Kai Li; Xiaojuan Geng; Yu Pan
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