Narciclasine mitigates sepsis-induced cardiac dysfunction by enhancing BNIP3-mediated mitophagy and suppressing ferroptosis. (PubMed, Free Radic Biol Med) - Jul 1, 2025 - "In neonatal rat cardiomyocytes challenged with LPS or the ferroptosis inducer erastin, Narc dose-dependently preserved cell viability, inhibited lipid peroxidation (BODIPY-C11 staining) and maintained intracellular glutathione...Together, these data establish that Narc mitigates SIMD by suppressing ferroptosis and preserving mitochondrial integrity through BNIP3-mediated mitophagy. This dual mechanism highlights Narc as a promising candidate for therapeutic intervention in sepsis-related cardiac injury."
Journal • Hematological Disorders • Infectious Disease • Inflammation • Metabolic Disorders • Septic Shock • GPX4
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Bifu Lin; Hao Xu; Minghe Jiang; Minsheng Wu; Pingping Qi; Qile Ye; Rong Tang; Shengkui Chen; Xiao Tang; Xiawei Wei; Yudan Pan
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