Cannabidiol Is a Potential Inhibitor of Ferroptosis in Human Articular Chondrocytes. (PubMed, J Cell Mol Med) - Jun 27, 2025 - "Exposure to known ferroptosis inducers RSL3, erastin and its analogue IKE, FINO2 and FIN56 led to a varying extent of reduced cell viability in two chondrocyte cell lines (in C-28/I2, T/C-28/A2) and primary chondrocytes, suggesting different sensitivity and defence mechanisms towards the respective substances. Increasing evidence has emerged for an important role of iron dyshomeostasis and ferroptosis in the onset and progression of various orthopaedic diseases, including osteoarthritis. Therefore, the here demonstrated and previously unreported cytoprotective and anti-oxidative effects of CBD in the context of ferroptosis have highly promising therapeutic implications."
Journal • Immunology • Orthopedics • Osteoarthritis • Pain • Rheumatology • GPX4
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A Wipplinger; C Ablinger; C Mayr; D Bekric; M Jakab; M Kittl; M Ritter; M Winklmayr
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