Dexmedetomidine protects against cerebral ischemia-reperfusion injury in mice by interfering with the crosstalk between autophagy and ferroptosis. (PubMed, Neurol Res) - Jun 27, 2025 - "After MCAO and reperfusion, treatments with DEX, DEX+Erastin, or DEX+rapamycin were administered. Notably, DEX's effects were negated by ferroptosis inducer Erastin or autophagy inducer RAPA. Dexmedetomidine modulates the crosstalk between autophagy and ferroptosis pathways, thereby protecting the mouse brain against ischemia-reperfusion injury and providing novel insights for the future treatment of ischemic stroke."
Journal • Preclinical • Cardiovascular • CNS Disorders • Ischemic stroke • Reperfusion Injury • BECN1 • GPX4 • MAP1A • SLC7A11
|
|
Cong Luo; Fengxian Yu; Yi Ou; Yujie Xu
|