HOTTIP suppresses ferroptosis via mediating DGCR8/miR‑214‑3p/GPX4 regulatory axis in osteosarcoma. (PubMed, Oncol Rep) - Jun 20, 2025 - "In the present study, HOTTIP was found to be downregulated in the Erastin‑treated OS cells...Mechanically, HOTTIP recruited the RNA binding protein DiGeorge Critical Region 8 (DGCR8) and influenced its protein stability, which disrupted miR‑214‑3p biogenesis and facilitated the de‑repression of glutathione peroxidase 4 transcription, eventually leading to preventing ferroptosis. Taken together, the present study demonstrated that HOTTIP suppressed ferroptosis in OS cells via DGCR8/micro RNA 214‑3p/GPX4 regulatory axis, which might provide insights to develop HOTTIP as a promising therapeutic target for OS patients."
Journal • Oncology • Osteosarcoma • Sarcoma • Solid Tumor • GPX4 • HOTTIP
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Chuan-Jian Shi; Feng-Xiang Pang; Jin-Fang Zhang; Nan Li; Rui-Jia Wen; Shou-Chang Ding; Shu-Ting Zhou; Yong-Xin Mai
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