CDKN1A attenuates ferroptosis in renal tubular epithelial cells and alleviates calcium oxalate crystal deposition under hyperoxaluric conditions. (PubMed, Urolithiasis) - Jun 19, 2025 - "In HK-2 cells, CDKN1A expression decreased upon Erastin exposure, and its knockdown enhanced ferroptosis sensitivity, confirming its potential suppressive role...These findings suggest that ferroptosis contributes to hyperoxaluria-associated renal epithelial injury and crystal deposition. CDKN1A may exert a protective role by modulating ferroptosis, providing mechanistic insight into oxalate-induced kidney injury and offering a basis for developing strategies to mitigate the risk of calcium oxalate stone formation."
Journal • Nephrology • Renal Calculi • Renal Disease • CDKN1A
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Chaoliang Xu; Chujiang He; Minglei Sha; Yi Shao; Zijie Xu
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