IGF2BP3 enhances ferroptosis resistance in colon cancer by stabilizing SLC7A11 and is regulated by miR-98-5p. (PubMed, Front Oncol) - Jun 18, 2025 - "Knockdown of IGF2BP3 enhanced erastin-induced ferroptosis sensitivity, marked by elevated MDA and ROS levels, reversible by ferrostatin-1...IGF2BP3 drives ferroptosis resistance in colon cancer by stabilizing SLC7A11 mRNA, while miR-98-5p antagonizes this pathway via IGF2BP3 downregulation. Targeting the miR-98-5p/IGF2BP3/SLC7A11 axis offers a promising therapeutic strategy to enhance ferroptosis sensitivity and improve colon cancer outcomes."
Journal • Colon Cancer • Colorectal Cancer • Oncology • Solid Tumor • IGF2BP3 • MIR98 • SLC7A11
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Congxing Liu; Guangqing Jiang; Hongzhou Shi; Junjie Wu; Qingwei Liu; Weimin Sun; Xin Shi; Yanxuan Ling; Yaya Sun; Yihong Zhang
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