Piezo1-Mediated Ferroptosis Delays Wound Healing in Aging Mice by Regulating the Transcriptional Activity of SLC7A11 through Activating Transcription Factor 3. (PubMed, Research (Wash D C)) - Jun 4, 2025 - "Elevated Piezo1 expression was observed in HUVECs treated with the senescence inducer doxorubicin (Doxo) and the ferroptosis inducer erastin and in aged wound tissue. Mechanistically, both genetic and pharmacological inhibition of Piezo1 promoted wound healing in aged tissues and regulated ferroptosis in senescent HUVECs through the CaMKII/ATF3/SLC7A11 pathway. In conclusion, these findings suggest that targeting Piezo1-mediated ferroptosis in senescent HUVECs offers a promising therapeutic approach for improving wound healing in the elderly."
Journal • Preclinical • ATF3 • SLC7A11
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Abdullah Al Mamun; Chen Jin; Du-Piao Zhang; Fu-Qiang Song; Jian Wang; Jian Xiao; Keqing Shi; Lei Yang; Lin-Yuan Jiang; Meng-Qi Jin; Ren-Wen Wan; Si-Ting Du; Xiao-Qiong Jiang; Xiao-Yu Dong; Yan-Zhen Feng; Yi-Feng Shi; Yu-Zhe Lin; Zhen Lin; Zheng-Lin Li; Zhi-Wen Luo; Zi-Miao Chen
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