Sirtuin-3 activation by honokiol attenuated anesthesia/surgery-induced cognitive impairment and neuronal ferroptosis via inhibiting mitochondrial GPX4 acetylation.

erastin - Whitehead Institute for Biomedical Research, Dana-Farber Cancer Institute, Columbia University, Prolexys

isoflurane - Generic mfg.

Sirtuin-3 activation by honokiol attenuated anesthesia/surgery-induced cognitive impairment and neuronal ferroptosis via inhibiting mitochondrial GPX4 acetylation. (PubMed, J Nanobiotechnology) - Jun 4, 2025 - "SIRT3 activation by HKL alleviates hippocampal neuronal ferroptosis in PND by suppressing mitochondrial GPX4 acetylation, providing a novel therapeutic strategy for the management of PND."
Journal • Alzheimer's Disease • Anesthesia • CNS Disorders • Cognitive Disorders • Developmental Disorders • Metabolic Disorders • Musculoskeletal Diseases • Orthopedics • GPX4 • SIRT3

http://www.ncbi.nlm.nih.gov/pubmed/40462120

Ailin Luo; Li Luo; Lian Zeng; Mingyue Li; Pengchao Hu; Qingsong Wang; Shiyong Li; Xuan Wang; Xudong Ding; Yilin Zhao; Yu Zhang

Jun 4, 2025