March6 Protects Against Acute Kidney Injury by Suppressing Renal Tubular Epithelial Cell Ferroptosis Through the Destabilization of P53 and ACSL4 Proteins. (PubMed, Inflammation) - May 30, 2025 - "Overexpression of March6 in HK-2 cells significantly counteracted Erastin-induced ferroptosis, whereas silencing March6 increased susceptibility...Collectively, March6 mitigates ferroptosis in renal tubular epithelial cells by promoting the degradation of ACSL4 and p53, thereby alleviating AKI progression. This study not only uncovers a novel regulatory mechanism of tubular epithelial cell ferroptosis in AKI but also provides a potential therapeutic target for its treatment."
Journal • Acute Kidney Injury • Cardiovascular • Nephrology • Renal Disease • Reperfusion Injury • ACSL4 • GPX4 • PACERR • PTGS2 • RNF6 • TP53
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Hongjuan Dong; Jie Feng; Liyi Xie; Ranran Kong; Yi Yang; Yurui Guo
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