Melatonin Alleviates Erastin-Induced Cell Death by Inhibiting Ferroptosis and Amyloid Precursor Protein Processing in Neuronal Cell Lines. (PubMed, Neurotox Res) - May 30, 2025 - "APP, β-site-APP cleaving enzyme 1 (BACE1), presenilin 1 (PS1) and Aβ production were alleviated in erastin-treated SH-SY5Y cells. In conclusion, melatonin effectively inhibits ferroptosis-related cell death and AD-like conditions induced by erastin in SH-SY5Y human neuroblastoma cell lines."
Journal • Preclinical • Alzheimer's Disease • CNS Disorders • Neuroblastoma • Oncology • Solid Tumor • Targeted Protein Degradation • ACSL4 • APP • GPX4
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Alliya Somnus; Piyarat Govitrapong; Puntita Siengdee; Suwakon Wongjaikam
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