Valproic acid induces ferroptosis and suppresses the proliferation of MDA-MB-231 cells by targeting FDFT1. (PubMed, Front Pharmacol) - May 29, 2025 - "To explore the impact of VPA in combination with ferrostatin-1, Erastin or RSL3, on MDA-MB-231 cell proliferation and ferroptosis, respective CCK-8, colony formation and WB assays were conducted. Additionally, we discovered that VPA may facilitate ferroptosis in MDA-MB-231 cells by negatively modulating the levels of the solute carrier family 7 member 11 (SLC7A11) protein through the upregulation of FDFT1 expression. In conclusion, this study elucidated that VPA induced the ferroptosis of MDA-MB-231 cells via targeting FDFT1, representing a novel mechanism underlying its efficacy in potentially inhibiting breast cancer."
Journal • Breast Cancer • Oncology • Solid Tumor • FDFT1 • SLC7A11
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Jiazhuo Liu; Ran Tao; Shuangping Liu; Shuxian Zhang; Xin Ren; Xingzhi Zhou; Yisong Yang
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