p53-mediated suppression of the SLC7 A11/GPX4 signaling pathway promotes trophoblast ferroptosis in preeclampsia. (PubMed, BMC Biol) - May 29, 2025 - "This study confirmed that trophoblast ferroptosis occurs in the pathological state of PE and that trophoblast are specifically sensitive to ferroptosis. p53 can mediate the SLC7A11/GPX4 signaling pathway to promote ferroptosis of trophoblast cells in the pathogenesis of PE. It is also speculated that increased p53 reactivity may mediate impaired angiogenesis in placental tissues."
Journal • Cardiovascular • Gynecology • CD34 • FLT1 • GPX4 • SLC7A11 • TP53
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Guiying Wang; Jianying Yan; Tingting Liao; Xia Xu
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