Ginkgolide B inhibits ferroptosis in PC12 cells and ameliorates the oxidative stress in spinal cord injury through activating Nrf2 signaling pathway. (PubMed, J Pharmacol Sci) - May 29, 2025 - "By using Erastin-induced ferroptosis in PC12 cells and a rat contusion SCI model, the present study demonstrated that GB significantly improved locomotor recovery, reduced neuronal loss, and attenuated histopathological damage...These findings reveal that GB alleviates SCI by inhibiting ferroptosis through Nrf2 activation, positioning it as a promising therapeutic agent. This study elucidates a novel mechanism linking Nrf2 signaling to ferroptosis suppression in SCI and provides a translational framework for repurposing GB in SCI treatment."
Journal • CNS Disorders • Orthopedics • ACSL4 • GPX4 • NQO1
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Jianfu Li; Tongtong Zhang; Wei She; Wenji Ma; Xingyong Li; Xunian Wu
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