Gypenosides Attenuates CORT-Induced Ferroptosis via Inhibiting TNF-α/NF-κB Signaling Pathway in PC12 Cells. (PubMed, Molecules) - May 28, 2025 - "Meanwhile, gypenosides attenuated ferroptosis agonist Erastin-induced ferroptosis in PC12 cells...Gypenosides also reduced corticosterone-induced release of inflammatory cytokines, the expression of TNFR1, and the phosphorylation of NF-κB and p53 in PC12 cells. These findings indicate that gypenosides attenuate corticosterone-induced ferroptosis by inhibiting TNF-α/NF-κB signaling pathway in PC12 cells."
Journal • CNS Disorders • Depression • Psychiatry • DMRT1 • GLS2 • GPX4 • SLC7A11 • TNFA • TNFRSF1A
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Haiyang Zhang; Jibin Wang; Jinghui Peng; Lingling Dai; Manyu Zhang; Shoujun Li; Yulin Hu; Zhicheng Gao
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