Inhibition of Cyclooxygenase-2 Upregulates the Nuclear Factor Erythroid 2-related Factor 2 Signaling Pathway to Mitigate Hepatocyte Ferroptosis in Chronic Liver Injury. (PubMed, J Clin Transl Hepatol) - May 19, 2025 - "In vitro, primary mouse hepatocytes were isolated and treated with dimethyl sulfoxide (DMSO), erastin+DMSO, etoricoxib+erastin+DMSO, and tBHQ+erastin+DMSO. Ferroptosis contributes to the progression of chronic liver injury. Inhibition of COX-2 upregulates Nrf2, mitigating hepatocyte ferroptosis in chronic liver injury."
Journal • Fibrosis • Hepatology • Immunology • Liver Cirrhosis • Liver Failure • GPX4
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Cheng-Wei Tang; Chong Zhao; Huan Tong; Jin-Hang Gao; Tian Lan; Yang Tai; Zhu Yang
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