Neferine Ameliorates Severe Acute Pancreatitis-Associated Intestinal Injury by Promoting NRF2-mediated Ferroptosis. (PubMed, Int J Biol Sci) - May 19, 2025 - "Furthermore, the protective effects of neferine were largely reversed by the Nrf2 inhibitor ML385 and the ferroptosis inducer erastin. This study demonstrates that neferine effectively alleviates SAP by inhibiting ferroptosis and restoring intestinal homeostasis, providing insights into new treatment options for SAP."
Journal • Pancreatitis • GPX4 • KEAP1 • NFE2L2
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Chen Chen; Kailiang Zhao; Kunpeng Wang; Lilong Zhang; Pingan Ding; Wanrong Jiang; Weixing Wang
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